Lions 2021 regular season Opponents officially set Jan 5, 2021 1:44:20 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by D6 on Jan 5, 2021 1:44:20 GMT -5 Detroit Lions’ 2021 regular-season opponents officially set...Plenty can and will change by the time each Lions game begins. Right now, on paper, this is a difficult list of opponents.