Big V and Levi O. will likely be on the Game Day Inactive list for this game.
Barring an additional injury, the only position that I believe the Lions might make a Practice Elevation for the LA Chargers game is Offensive Tackle (based on the health of Dan Skipper.).
I think the Lions will keep Donovan Peoples-Jones out of this game. With the plan of DPP getting healthier and more familiar with the Lions Offensive System, before he makes his Lions game deput.